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The application of artificial intelligence (AI) to address challenges in health care is almost universally described as transformative. Acknowledging the rapid pace at which tools incorporating AI have advanced toward clinical practice, prior JAMA editorials1,2 noted the importance of ensuring the rigorous evaluation of approaches using AI at every stage of development. It emphasized the JAMA Network’s commitment to apply the same standards and principles that would be expected for any other new technology. Today we underscore that commitment with the launch of JAMA+ AI, a window into the world of AI across the JAMA Network and a first stop for authors and readers seeking the best science and commentary on AI and its application to medicine and public health. JAMA+ AI is a place to bring together the accelerating literature on AI across JAMA, JAMA Network Open, and the JAMA specialty journals, while recognizing that AI in medicine is still embedded in medicine and best understood in the context of a range of innovations with a common goal—namely, improving the health and care of patients. To maximize the value of these articles for readers, we will augment the best original research and Viewpoints from the JAMA Network with new content: Q&A interviews with authors, videos showing AI tools in action, debates about the future of AI in health. A regular podcast will provide more perspective from authors and other experts, as in a recent podcast with US Surgeon General Vivek Murthy addressing social media.3 For clinicians already well-versed in

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(4 to 7)6 (3 to 6)−1 (−2 to 0)1.16 (0.84 to 1.61) At 28 d6 (6 to 7)6 (6 to 7)0 (−1 to 1)0.97 (0.69 to 1.38)All-cause, all-location death, No. (%)n = 241n = 236 At 14 d18 (7.5)14 (5.9)1.5 (−2.9 to 6.0)1.56 (0.68 to 3.57) At 28 d25 (10.4)25 (10.6)−0.2 (−5.7 to 5.3)1.07 (0.54 to 2.09)Time to recovery in days, median (IQR)5 (1 to 14)6 (1 to 15)−1 (−3 to 1)0.97 (0.69 to 1.35)Composite of death or ECMO through 28 d, No./total No. (%)29/241 (12.0)28/236 (11.9)0.2 (−5.6 to 6.0)1.13 (0.60 to 2.14)Support-free days through day 28, median (IQR) Hospital-free days21 (11 to 24)20 (10 to 24)1 (−1 to 3)1.17 (0.85 to 1.61) Oxygen-free days21 (0 to 27)20 (0 to 27)1 (−2 to 4)0.96 (0.68 to 1.34) ICU-free days28 (21 to 28)28 (18 to 28)0 (0 to 0)1.26 (0.84 to 1.88) Ventilator-free days28 (28 to 28)28 (28 to 28)0d1.26 (0.76 to 2.08) Vasopressor-free days28 (28 to 28)28 (28 to 28)0d1.03 (0.61 to 1.72)Systematically collected safety events, No. (%)e Cytopeniaf92 (38.0)87 (36.7)1.3 (−7.4 to 10.0)1.06 (0.73 to 1.53) AST or ALT ≥2 times upper limit of normal50 (20.7)65 (27.4)−6.8 (−14.4 to 0.9)0.69 (0.45 to 1.05) Cardiac arrest treated with CPRg10 (4.1)4 (1.7)2.5 (−0.8 to 5.6)2.51 (0.78 to 8.12) Symptomatic hypoglycemiah10 (4.1)8 (3.4)0.8 (−2.8 to 4.3)1.23 (0.48 to 3.18) Ventricular tachyarrhythmiai5 (2.1)6 (2.5)−0.5 (−3.4 to 2.4)0.81 (0.24 to 2.70) Seizure1 (0.4)00.4 (−1.0 to 1.8)Patients with ≥1 SAEs reportedj14 (5.8)11 (4.6)1.1 (−3.0 to 5.2)1.26 (0.56 to 2.84) November 9, 2020 JAMA. 2020;324(21):2165-2176. doi:10.1001/jama.2020.22240 visual abstract icon editorial comment icon author interview icon Interviews multimedia icon Multimedia audio icon Original Investigation Treatment With Hydroxychloroquine or Azithromycin and In-Hospital Mortality in Patients With COVID-19 Eli S. Rosenberg, PhD; Elizabeth M. Dufort, MD; Tomoko Udo, PhD; Larissa A. Wilberschied, MS; Jessica Kumar, DO; James Tesoriero, PhD; Patti Weinberg, PA; James Kirkwood, MPH; Alison Muse, MPH; Jack DeHovitz, MD; Debra S. Blog, MD; Brad Hutton, MPH; David R. Holtgrave, PhD; Howard A. Zucker, MD JAMA JAMA Guide to Statistics and Methods Regression Models for Ordinal Outcomes Benjamin French, PhD; Matthew S. Shotwell, PhD JAMA Original Investigation Efficacy. Listen to music by Jama Trio on Apple Music. Find top songs and albums by Jama Trio including Blues della citt di chiusura (feat. Davide Gammon Jama Trio), Blues di Elvis (feat. Davide Gammon Jama Trio) and more.

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AI applications in medicine, the channel provides a way to keep up with a flood of new work all in one place, or delve deeper into a particular topic. For other interested readers looking to understand the burgeoning field, JAMA+ AI also provides an opportunity to learn and master aspects of this new technology. Clinicians, researchers, and policymakers have heard the buzzwords but may feel like they lack the foundation to critically approach articles about AI. JAMA+ AI allows us the freedom to enrich our articles with additional materials, aimed at making them more accessible. The reality is that JAMA Network readers already have much of the knowledge they need to interpret studies that incorporate AI, if we can demystify the technology. There is a third group who may not yet read JAMA yet: the computer scientists, engineers, and other technologists who want to apply AI to impact health. JAMA+ AI will aim to increase opportunity for interaction between the people building AI and the people using AI in health—clinicians, but also health systems and ultimately patients. In the absence of this conversation, critical needs in health care remain neglected, while developers’ new technology gets ignored because it solves the wrong problem, or solves the problem wrong. One thing that will not change in JAMA+ AI is the JAMA Network’s commitment to being a platform for elucidation, discussion, and debate of the cross-cutting themes in modern medicine: recognizing and mitigating bias4; acknowledging and addressing the global variation in health care

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Day 90e Yes60 (88.2)46 (85.2).623.1 (−9.1 to 15.2)OR: 0.77 (0.27 to 2.17)h Noi8 (11.8)8 (14.8)Requirement of RRT on day 90, No./total No. patients alive at day 90 (%)9/67 (13.4)j8/53 (15.1)k.80−1.7 (−14.3 to 11.0)OR: 0.87 (0.31 to 2.44)ICU stay, median (Q1, Q3), d15.5 (8.0, 28.0)16.0 (6.8, 30.0).950.0 (−3.0 to 3.0)ICU stay, median (Q1, Q3), dl19 (9, 29)22 (12, 36).33−3.0 (−12.0 to 4.5)HR: 0.85 (0.61 to 1.19)mHospital stay, median (Q1, Q3), d33.0 (18.0, 58.0)43.0 (19.5, 81.3).05−9.0 (−19.0 to 0.0)Hospital stay, median (Q1, Q3), dn51 (31, 74)82 (67, >90)−37 (−∞ to −19.5)HR: 0.34 (0.22 to 0.52)oDuration of mechanical ventilation, median (Q1, Q3), h125.5 (41, 203)181.0 (65, 413).002−60.0 (−110.0 to −22.0) Original Investigation Caring for the Critically Ill Patient May 24/31, 2016 Effect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury: The ELAIN Randomized Clinical Trial JAMA. 2016;315(20):2190-2199. doi:10.1001/jama.2016.5828 visual abstract icon editorial comment icon author interview icon Interviews multimedia icon Multimedia audio icon Comment & Response Timing of Initiation of Renal Replacement Therapy in Patients With Severe AKI Hong Wang, MD, PhD; Chenglong Li, MD; Xiaotong Hou, MD, PhD JAMA Comment & Response Timing of Initiation of Renal Replacement Therapy in Patients With Severe AKI Paul J. Young, PhD; Rinaldo Bellomo, MD; Giovanni Landoni, MD JAMA Comment & Response Timing of Initiation of Renal Replacement Therapy in Patients With Severe AKI Bruno Adler Maccagnan Pinheiro Besen, MD; Otavio T. Ranzani, MD, MSc; Marcelo Park, MD, PhD JAMA Comment & Response Timing of Initiation of Renal Replacement Therapy in Patients With Severe AKI Alexander Zarbock, MD; John A. Kellum, MD JAMA Correction Errors in the Text and Supplement JAMA Comment & Response Timing of Initiation of Renal Replacement Therapy in Patients With Severe AKI Christophe Vinsonneau, MD, MSc; Mehran Monchi, MD JAMA Importance Optimal timing of initiation of renal replacement therapy (RRT) for severe acute kidney injury (AKI) but without life-threatening indications is still unknown.Objective To determine whether early initiation of RRT in patients who are critically ill with AKI reduces 90-day all-cause mortality.Design, Setting, and Participants Single-center randomized clinical trial of 231

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Of care for future generations.Invitae designed comprehensive panels to maximize detection rates for individuals with a personal or family history of mixed cancers. You can take action and encourage your patients to understand their genetic risk.Invitae offers broad hereditary cancer panels that provide a holistic view, enabling personalized care. Order test kits, get straightforward results, and access expert support on the Invitae website.*assigned female at birth†assigned male at birthReferencesBreast cancer statistics: World cancer research fund international. WCRF International. April 14, 2022. Accessed September 14, 2023. N, et al. BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer. 1998 Sep 4 [Updated 2023 Sep 21]. In: Adam MP, Mirzaa GM, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2023.Hereditary cancer syndromes and risk assessment. ACOG. Updated 2020. Accessed August 25, 2023. H, et al. Genet Med. 2015;17(1):70–87.National Cancer Institute. BRCA1 and BRCA2: Cancer risks and management (PDQ®)–health professional version [Internet]. National Cancer Institute. Updated 2023. Accessed May 23, 2023. T, et al. JAMA Oncol. 2020;6(9):1460–1463.LaDuca, et al. Genetics in Medicine. 2020;22(2)407–415.Samadder NJ, et al. JAMA Oncol. 2021;7(2):230–237.Whitworth PW, et al. JAMA Netw Open. 2022;5(9):e2232787.Kurian AW, et al. JAMA. 2023;330(1):43–51.Yang S, et al. Ann Surg Oncol. 2018;25(10):2925–2931.Samader NJ, et al. JAMA Oncol. 2021;7(2):230–237.American Society of Breast Surgeons. Consensus guideline on genetic testing for hereditary breast cancer. Issued February 14, 2019.Hereditary cancer syndromes and risk assessment. ACOG. Updated December 2019. Accessed October 3, 2023. EV, et al. BMC Med. 2021;19:199.

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Jama Software® Community ReportsJama Software® is focused on maximizing innovation success in multidisciplinary engineering organizations. Numerous firsts for humanity in fields such as fuel cells, electrification, space, software-defined vehicles, surgical robotics, and more all rely on Jama Connect® requirements management software to minimize the risk of defects, rework, cost overruns, and recalls. Using Jama Connect, engineering organizations can now intelligently manage the development process by leveraging Live Traceability™ across best-of-breed tools to measurably improve outcomes. Our rapidly growing customer base spans the automotive, medical device, life sciences, semiconductor, aerospace & defense, industrial manufacturing, consumer electronics, financial services, and insurance industries. visit jamasoftware.com.Please visit dev.jamasoftware.com for additional resources and join the discussion in our community community.jamasoftware.com.Community Report Downloads:Jama Software's EESR custom reporting team in partnership with Jama Software's Consulting team are happy to provide our customers a collection of public use custom reports. Each of these community reports are generic custom reports ready to be installed to any customer instance to satisfy a specific common need. Each report is either written with Velocity, so if you are an on-premises customer and have experience with the appropriate platform, you can manipulate them to suit your needs.Please be aware that these custom reports are complimentary and come as-is but should a bug be identfied the EESR Team will be happy to resolve it. Should you wish to request a enhancement request please review the 'Requesting Modified Community Report Versions' section below.Installation Process:On-Prem & Cloud Customers:Each community report includes a ReadMe of about the report including the installation instructions and configuration settings. Some reports have multiple versions which cater to different databases, so pay close attention that you download the correct one.Download the community report file you would like installed to your instance.Navigate to the Admin screen of your instance.On the left navigation menu select the Reports option.Click on the Add Report option in the top right hand corner of this screen.In the installation menu that pops up input the same information as shown in the reports ReadMe installation instructions image.Ensure that the Name field in the Criteria section are inputted exactly the same as shown in the installation image otherwise your report parameters will not work.Select the Save button to finalize your report installation.Requesting Modified Community Report Versions:While Jama Software Support will not assist with the use or modification of these reports you can make a custom report request through your Jama Software Consultant or Jama Software Account Manager to have a modified version created for you as a services engagement. This can allow you to add new functionality, formatting changes, or different data unique to your company needs for any of these reports.Custom Reporting ServicesShould you be interested in having a custom report created to satisfy your companies needs or having custom report training to learn how to create your own reports you can speak with your Jama Software Consultant or Jama Software Account Manager to make a EESR custom report request. These offering can be funded as individual services engagements, existing. Listen to music by Jama Trio on Apple Music. Find top songs and albums by Jama Trio including Blues della citt di chiusura (feat. Davide Gammon Jama Trio), Blues di Elvis (feat. Davide Gammon Jama Trio) and more. Jeremiah by Jama Trio, released

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Resources5,6; preserving patient-centered care7; and educating the next generation of clinicians.8 In 1987, JAMA published one of the first applications of AI in medicine in the modern era, a clinical decision support system called DXplain.9 In that article, the authors noted “the increasing complexity and scope of the medical knowledge base,” “increasing fragmentation and specialization of medical practice,” and “increasing willingness among physicians to utilize computer technology in all phases of patient care activity.” Nearly 4 decades later, these prescient observations still ring true. AI as a technology carries enormous promise: improving diagnosis, supporting decisions about treatment, even delivering treatment. It also brings new challenges, as clinicians adjust to having another voice in the clinic, while seeking to preserve the essential humanness of clinical practice. Regulators must adapt to a technology that is different from others in its capacity to change rapidly even after deployment, and in the difficulty in fully understanding how it works in many cases. Policymakers must also address this moving target, developing rules that ensure it will enhance care for all. Medical educators must find ways to teach the next generation of clinicians how to incorporate AI in practice. By drawing on research and perspectives from across the JAMA Network, augmented with new materials specific to the channel, JAMA+ AI will seek to catalyze these conversations. Back to top Article Information Corresponding Author: Roy H. Perlis, MD, MSc, JAMA ([email protected]).Published Online: October 8, 2024. doi:10.1001/jama.2024.21559Conflict of Interest Disclosures: Dr Perlis reported receiving personal fees for

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Our retirement calculator uses your current age and pension savings to give you an idea of what your retirement income could look like. What might your retirement look like?We have designed this calculator to help you answer questions like ‘How much do I need to retire?’ and ‘When can I retire?’.Move the sliders along to personalise the results. Hover over the (i) icons below to find out more about the different fields. You’re on track to have at retirement.If you take per year, this will last until age . Desired Annual Retirement Income Current Combined Pension Pot Personal monthly contribution Employer monthly contribution Personal one-off contribution Include full State Pension Full tax-free cash at retirement This calculation assumes a mid-level growth rate of 5% per year, inflation of 2% per year and pension fees of 0.7%. Growth, inflation and ongoing charges will vary. The aim of this pension calculator is to give you an idea of the level of income your current pension benefits could provide you with and/or how much you might need to save into a pension to get the income you’re aiming for in retirement. It’s not personal advice or suitable for calculating the potential income from a defined benefit scheme, e.g. a final salary scheme. If you’re not sure what’s best for your situation, you should seek personal advice.The value of investments and any income from them can fall and you may get back less than you invested. Latest News & Guides Thought leadership Market Briefing: 10th March Rory McPherson, March 10th 2025 Wren Sterling announces trio of acquisitions bringing £300m+ of AUM March 5th 2025 Thought leadership Market Briefing: 3rd March Rory McPherson, March 3rd 2025 Planning for retirement Saving for retirement guide Saving for retirement guide We want our clients to be looking forward. Listen to music by Jama Trio on Apple Music. Find top songs and albums by Jama Trio including Blues della citt di chiusura (feat. Davide Gammon Jama Trio), Blues di Elvis (feat. Davide Gammon Jama Trio) and more.

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Lescot T, Futier E, Paugam-Burtz C, Seguin P, Ferrandiere M, Lasocki S, Mimoz O, Hengy B, Sannini A, Pottecher J, Abback PS, Riu B, Belafia F, Constantin JM, Masseret E, Beaussier M, Verzilli D, De Jong A, Chanques G, Brochard L, Molinari N. Effect of noninvasive ventilation on tracheal reintubation among patients with hypoxemic respiratory failure following abdominal surgery: a randomized clinical trial. JAMA. 2016;315:1345–53.Article CAS Google Scholar Annane D, Sébille V, Charpentier C, Bollaert PE, François B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troché G, Chaumet-Riffaud P, Bellissant E. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA. 2002;288:862–71.Article CAS Google Scholar Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 Countries. JAMA. 2016;315:788–800.Article CAS Google Scholar Collins GS, Reitsma JB, Altman DG, Moons KG. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. BMJ. 2015;350:7594.Article Google Scholar Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, Ioannidis JP, Straus S, Thorlund K, Jansen JP, Mulrow C, Catalá-López F, Gøtzsche PC, Dickersin K, Boutron I, Altman DG, Moher D. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med. 2015;162:777–84.Article Google Scholar Garfield E. The history and meaning of the journal impact factor. JAMA. 2006;295:90–3.Article CAS Google Scholar Ospina-Tascón GABG, Vincent JL. Multicenter, randomized, controlled trials evaluating mortality in intensive care: doomed to fail? Crit Care Med. 2008;36:1311–22.Article Google Scholar Harhay MO, Wagner